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MBD2

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GENERAL INFORMATION

Gene name

 MBD2

Gene description

 Methyl-CpG binding domain protein 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA067582 , HPA067615
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA067582 A-431 No staining    
HPA067582 HaCaT Nucleoplasm
HPA067582 U-2 OS No staining    
HPA067615 A-431 Nucleoplasm
HPA067615 HaCaT Nucleoplasm
Cytosol
HPA067615 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 MBD2

Synonyms

Description

 Methyl-CpG binding domain protein 2 (HGNC Symbol)

Entrez gene summary

 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

 18

Cytoband

 q21.2

Chromosome location (bp)

 54151601 - 54224788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134046 (version 83.38)

Entrez gene

 8932

UniProt

 Q9UBB5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBB5

Antibodypedia

 MBD2 antibodies

PROTEIN BROWSER
MBD2-001
MBD2-002
MBD2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBD2-001
ENSP00000256429
ENST00000256429
Q9UBB5 [Direct mapping]
Methyl-CpG-binding domain protein 2
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0000792 [heterochromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003696 [satellite DNA binding]
GO:0003729 [mRNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006346 [methylation-dependent chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0008327 [methyl-CpG binding]
GO:0010467 [gene expression]
GO:0019904 [protein domain specific binding]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0031492 [nucleosomal DNA binding]
GO:0035197 [siRNA binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0042127 [regulation of cell proliferation]
GO:0042711 [maternal behavior]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0043623 [cellular protein complex assembly]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070742 [C2H2 zinc finger domain binding]
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 411 aa
43.3 kDa 		No 0
MBD2-002
ENSP00000464554
ENST00000583046
Q9UBB5 [Direct mapping]
Methyl-CpG-binding domain protein 2
A0A024R2B8 [Target identity:100%; Query identity:100%]
Methyl-CpG binding domain protein 2, isoform CRA_b
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   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003696 [satellite DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006346 [methylation-dependent chromatin silencing]
GO:0006351 [transcription, DNA-templated]
GO:0008327 [methyl-CpG binding]
GO:0010467 [gene expression]
GO:0019904 [protein domain specific binding]
GO:0031492 [nucleosomal DNA binding]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0070742 [C2H2 zinc finger domain binding]
Show all
 302 aa
31.7 kDa 		No 0
MBD2-005
ENSP00000381435
ENST00000398398
X6RBL6 [Direct mapping]
Methyl-CpG-binding domain protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
Show all
 241 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.