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Most malignancies showed weak to moderate cytoplasmic staining. A few cases of hepatocellular carcinomas were strongly stained while several cases of malignant lymphomas and renal cancers were negative.
GENE INFORMATION
Gene name
IER3IP1
Synonyms
Description
Immediate early response 3 interacting protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]
