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CD180

GENERAL INFORMATION

Gene name

 CD180

Gene description

 CD180 molecule

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (spleen, small intestine)
FANTOM5:Group enriched (tonsil, spleen, appendix, lymph node, adipose tissue)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in a subset of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA003740
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, spleen, appendix, lymph node, adipose tissue)

GENE INFORMATION

Gene name

 CD180 (HGNC Symbol)

Synonyms

 LY64, Ly78, RP105

Description

 CD180 molecule (HGNC Symbol)

Entrez gene summary

 CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 67179613 - 67196799

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134061 (version 83.38)

Entrez gene

 4064

UniProt

 Q99467 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99467

Antibodypedia

 CD180 antibodies

PROTEIN BROWSER
CD180-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD180-001
ENSP00000256447
ENST00000256447
Q99467 [Direct mapping]
CD180 antigen
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002322 [B cell proliferation involved in immune response]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0016021 [integral component of membrane]
GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway]
GO:0045087 [innate immune response]
GO:0071222 [cellular response to lipopolysaccharide]
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 661 aa
74.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.