Expression of EDEM1 in cancer - Summary

CANCER ATLAS

Gene description

ER degradation enhancer, mannosidase alpha-like 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029565

GENE INFORMATION
Gene name	EDEM1 (HGNC Symbol)
Synonyms	EDEM, KIAA0212
Description	ER degradation enhancer, mannosidase alpha-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p26.1
Chromosome location (bp)	5187646 - 5219957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134109 (version 83.38)
Entrez gene	9695
UniProt	Q92611 (UniProt - Evidence at protein level)
neXtProt	NX_Q92611
Antibodypedia	EDEM1 antibodies

PROTEIN BROWSER

EDEM1-001	EDEM1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EDEM1-001 ENSP00000256497 ENST00000256497	Q92611 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 1 A0A024R2D5 [Target identity:100%; Query identity:100%] alpha-1,2-Mannosidase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0036510 [trimming of terminal mannose on C branch] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051787 [misfolded protein binding] GO:0097466 [glycoprotein ERAD pathway] GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	657 aa 73.8 kDa	No	0
EDEM1-003 ENSP00000394099 ENST00000445686	Q92611 [Direct mapping] ER degradation-enhancing alpha-mannosidase-like protein 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004571 [mannosyl-oligosaccharide 1,2-alpha-mannosidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0006491 [N-glycan processing] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044322 [endoplasmic reticulum quality control compartment] GO:0051787 [misfolded protein binding] GO:0097466 [glycoprotein ERAD pathway] GO:1904154 [positive regulation of retrograde protein transport, ER to cytosol] GO:1904382 [mannose trimming involved in glycoprotein ERAD pathway] Show all	376 aa 42.7 kDa	No	0