Expression of CHL1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cell adhesion molecule L1-like

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA003345	CAB026120

GENE INFORMATION
Gene name	CHL1 (HGNC Symbol)
Synonyms	CALL, FLJ44930, L1CAM2, MGC132578
Description	Cell adhesion molecule L1-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011]
Chromosome	3
Cytoband	p26.3
Chromosome location (bp)	196596 - 409417
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134121 (version 83.38)
Entrez gene	10752
UniProt	O00533 (UniProt - Evidence at protein level)
neXtProt	NX_O00533
Antibodypedia	CHL1 antibodies

PROTEIN BROWSER

CHL1-001	CHL1-002	CHL1-006	CHL1-007	CHL1-008	CHL1-010	CHL1-013	CHL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHL1-001 ENSP00000256509 ENST00000256509	O00533 [Direct mapping] Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0008344 [adult locomotory behavior] GO:0016021 [integral component of membrane] GO:0030425 [dendrite] GO:0031175 [neuron projection development] GO:0035640 [exploration behavior] GO:0043524 [negative regulation of neuron apoptotic process] GO:0045177 [apical part of cell] GO:0050890 [cognition] GO:0070062 [extracellular exosome] Show all	1224 aa 136.7 kDa	Yes	1
CHL1-002 ENSP00000380628 ENST00000397491	O00533 [Direct mapping] Neural cell adhesion molecule L1-like protein Processed neural cell adhesion molecule L1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	1208 aa 135.1 kDa	Yes	1
CHL1-006 ENSP00000403311 ENST00000427688	C9JEY3 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.5 kDa	Yes	0
CHL1-007 ENSP00000413628 ENST00000421198	C9JW79 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	96 aa 11 kDa	Yes	0
CHL1-008 ENSP00000397445 ENST00000435603	C9J905 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	181 aa 20.8 kDa	Yes	0
CHL1-010 ENSP00000390440 ENST00000449294	C9JH37 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	85 aa 9.8 kDa	Yes	0
CHL1-013 ENSP00000395239 ENST00000445697	H7C0J0 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	358 aa 39.4 kDa	No	1
CHL1-201 ENSP00000483512 ENST00000620033	A0A087X0M8 [Direct mapping] Neural cell adhesion molecule L1-like protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1171 aa 130.8 kDa	Yes	1