Cell atlas - DPH6 - The Human Protein Atlas

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DPH6

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DPH6
Gene description	Diphthamine biosynthesis 6
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (validated)
Additional location	In addition localized to the Nucleus (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA042976 , HPA055496
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus.

Main location

Nucleoli (validated)

Additional location

Nucleus (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA042976	HEK 293	Nucleus
HPA042976	HEK 293	Nucleoli
HPA042976	Hep G2	Nucleus
HPA042976	Hep G2	Nucleoli
HPA042976	U-2 OS	Nucleus
HPA042976	U-2 OS	Nucleoli
HPA055496	HEK 293	Nucleoli
HPA055496	Hep G2	Nucleus
HPA055496	Hep G2	Nucleoli
HPA055496	U-2 OS	Nucleoli

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000057147 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA042976	NIH 3T3	No staining

GENE INFORMATION
Gene name	DPH6 (HGNC Symbol)
Synonyms	ATPBD4, MGC14798
Description	Diphthamine biosynthesis 6 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q14
Chromosome location (bp)	35217345 - 35546193
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134146 (version 83.38)
Entrez gene	89978
UniProt	Q7L8W6 (UniProt - Evidence at protein level)
neXtProt	NX_Q7L8W6
Antibodypedia	DPH6 antibodies

PROTEIN BROWSER

DPH6-001	DPH6-002	DPH6-004	DPH6-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DPH6-001 ENSP00000256538 ENST00000256538	Q7L8W6 [Direct mapping] Diphthine--ammonia ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0017178 [diphthine-ammonia ligase activity] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0031647 [regulation of protein stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	267 aa 30.3 kDa	No	0
DPH6-002 ENSP00000406976 ENST00000440392	Q7L8W6 [Direct mapping] Diphthine--ammonia ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0017178 [diphthine-ammonia ligase activity] GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine] GO:0031647 [regulation of protein stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	165 aa 18.7 kDa	No	0
DPH6-004 ENSP00000453967 ENST00000561411	H0YND7 [Direct mapping] Diphthine--ammonia ligase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.5 kDa	No	0
DPH6-009 ENSP00000454015 ENST00000558266	H0YNH5 [Direct mapping] Diphthine--ammonia ligase Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.