Tissue expression of FKBP11 - Summary - The Human Protein Atlas

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FKBP11

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FKBP11
Gene description	FK506 binding protein 11, 19 kDa
Protein class	Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in pancreas, lymphoid organs and immune cells in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA041709
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	FKBP11 (HGNC Symbol)
Synonyms	FKBP19
Description	FK506 binding protein 11, 19 kDa (HGNC Symbol)
Entrez gene summary	FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	48921518 - 48926474
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134285 (version 83.38)
Entrez gene	51303
UniProt	Q9NYL4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYL4
Antibodypedia	FKBP11 antibodies

PROTEIN BROWSER

FKBP11-001	FKBP11-002	FKBP11-006	FKBP11-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP11-001 ENSP00000449751 ENST00000550765	Q9NYL4 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP11 Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061077 [chaperone-mediated protein folding] Show all	201 aa 22.2 kDa	Yes	1
FKBP11-002 ENSP00000396874 ENST00000453172	Q9NYL4 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP11 Show all	Enzymes ENZYME proteins Isomerase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0061077 [chaperone-mediated protein folding] Show all	146 aa 15.8 kDa	Yes	0
FKBP11-006 ENSP00000447911 ENST00000552878	F8VU90 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0061077 [chaperone-mediated protein folding] Show all	182 aa 19.8 kDa	Yes	0
FKBP11-009 ENSP00000412403 ENST00000444214	E9PAR0 [Direct mapping] Peptidyl-prolyl cis-trans isomerase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005528 [FK506 binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016021 [integral component of membrane] GO:0061077 [chaperone-mediated protein folding] Show all	99 aa 11.2 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.