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YWHAQ

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GENERAL INFORMATION

Gene name

 YWHAQ

Gene description

 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nucleoplasm (uncertain)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB010286
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (supported)

Additional location

 Nucleoplasm (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB010286 A-431 Cytosol
CAB010286 U-2 OS Nucleoplasm
Cytosol
CAB010286 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 YWHAQ (HGNC Symbol)

Synonyms

 14-3-3, HS1

Description

 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta (HGNC Symbol)

Entrez gene summary

 This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 9583972 - 9631014

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134308 (version 83.38)

Entrez gene

 10971

UniProt

 P27348 (UniProt - Evidence at protein level)

neXtProt

 NX_P27348

Antibodypedia

 YWHAQ antibodies

PROTEIN BROWSER
YWHAQ-001
YWHAQ-002
YWHAQ-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
YWHAQ-001
ENSP00000238081
ENST00000238081
P27348 [Direct mapping]
14-3-3 protein theta
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0043234 [protein complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
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 245 aa
27.8 kDa 		No 0
YWHAQ-002
ENSP00000371267
ENST00000381844
P27348 [Direct mapping]
14-3-3 protein theta
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005925 [focal adhesion]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008022 [protein C-terminus binding]
GO:0010467 [gene expression]
GO:0012501 [programmed cell death]
GO:0016020 [membrane]
GO:0019904 [protein domain specific binding]
GO:0021762 [substantia nigra development]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0034766 [negative regulation of ion transmembrane transport]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0047485 [protein N-terminus binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0071889 [14-3-3 protein binding]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
Show all
 245 aa
27.8 kDa 		No 0
YWHAQ-005
ENSP00000398990
ENST00000446619
E9PG15 [Direct mapping]
14-3-3 protein theta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0019904 [protein domain specific binding]
Show all
 149 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.