Cell atlas - GRHL1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GRHL1
Gene description	Grainyhead-like transcription factor 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the Golgi apparatus & vesicles.
RNA cell category	Cell line enhanced (BEWO, SK-BR-3)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)
Additional location	In addition localized to the Golgi apparatus (validated), Vesicles (validated)
Mouse	Localized to the Vesicles in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA005798 , HPA006420
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, SK-BR-3) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the Golgi apparatus & vesicles.

Main location

Nucleus (validated)

Additional location

Golgi apparatus (validated), Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA005798	A-431	Nucleus
HPA005798	A-431	Golgi apparatus
HPA005798	U-251 MG	Nucleus
HPA005798	U-251 MG	Cytosol
HPA006420	A-431	Nucleoplasm
HPA006420	A-431	Vesicles
HPA006420	U-2 OS	Nucleoplasm
HPA006420	U-2 OS	Vesicles
HPA006420	U-251 MG	Nucleoplasm
		Vesicles
		Cytosol

MOUSE CELLS

Main location

Vesicles

Additional location

Nucleoplasm

Mouse gene

ENSMUSG00000020656 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA006420	NIH 3T3	Nucleoplasm
	HPA006420	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	GRHL1 (HGNC Symbol)
Synonyms	LBP-32, MGR, TFCP2L2
Description	Grainyhead-like transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
Chromosome	2
Cytoband	p25.1
Chromosome location (bp)	9951693 - 10002277
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134317 (version 83.38)
Entrez gene	29841
UniProt	Q9NZI5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZI5
Antibodypedia	GRHL1 antibodies

PROTEIN BROWSER

GRHL1-001	GRHL1-005	GRHL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRHL1-001 ENSP00000324693 ENST00000324907	Q9NZI5 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	618 aa 70.1 kDa	No	0
GRHL1-005 ENSP00000419831 ENST00000480736	C9JYY8 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 8.2 kDa	No	0
GRHL1-201 ENSP00000384209 ENST00000405379	Q9NZI5 [Direct mapping] Grainyhead-like protein 1 homolog Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0008544 [epidermis development] GO:0031490 [chromatin DNA binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	429 aa 49.2 kDa	No	0