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LPIN1

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GENERAL INFORMATION

Gene name

 LPIN1

Gene description

 Lipin 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (approved)

Additional location

 In addition localized to the Nucleus (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA038021
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nucleus.

Main location

 Nucleoli fibrillar center (approved)

Additional location

 Nucleus (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA038021 A-431 Nucleus
Nucleoli fibrillar center
HPA038021 U-2 OS Nucleus
Nucleoli fibrillar center
HPA038021 U-251 MG Nucleus
Nucleoli fibrillar center

GENE INFORMATION

Gene name

 LPIN1 (HGNC Symbol)

Synonyms

 KIAA0188

Description

 Lipin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined. [provided by RefSeq, May 2012]

Chromosome

 2

Cytoband

 p25.1

Chromosome location (bp)

 11677595 - 11827409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134324 (version 83.38)

Entrez gene

 23175

UniProt

 Q14693 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14693

Antibodypedia

 LPIN1 antibodies

PROTEIN BROWSER
LPIN1-001
LPIN1-004
LPIN1-006
LPIN1-007
LPIN1-010
LPIN1-019
LPIN1-201
LPIN1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LPIN1-001
ENSP00000256720
ENST00000256720
Q14693 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003674 [molecular_function]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006642 [triglyceride mobilization]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 890 aa
98.7 kDa 		No 0
LPIN1-004
ENSP00000379405
ENST00000396098
Q14693 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003674 [molecular_function]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006642 [triglyceride mobilization]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 459 aa
50.5 kDa 		No 0
LPIN1-006
ENSP00000412578
ENST00000441684
C9IYP2 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005741 [mitochondrial outer membrane]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 96 aa
10.7 kDa 		No 0
LPIN1-007
ENSP00000392424
ENST00000423495
C9J278 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005741 [mitochondrial outer membrane]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 28 aa
3 kDa 		No 0
LPIN1-010
ENSP00000413714
ENST00000454151
H7C3T1 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005741 [mitochondrial outer membrane]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 194 aa
21.7 kDa 		No 0
LPIN1-019
ENSP00000397908
ENST00000449576
Q14693 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003674 [molecular_function]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006642 [triglyceride mobilization]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0031100 [organ regeneration]
GO:0031965 [nuclear membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 975 aa
107.9 kDa 		No 0
LPIN1-201
ENSP00000379404
ENST00000396097
Q14693 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003674 [molecular_function]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006642 [triglyceride mobilization]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 932 aa
103 kDa 		No 0
LPIN1-202
ENSP00000401522
ENST00000425416
Q14693 [Direct mapping]
Phosphatidate phosphatase LPIN1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0003674 [molecular_function]
GO:0003713 [transcription coactivator activity]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006642 [triglyceride mobilization]
GO:0006644 [phospholipid metabolic process]
GO:0006646 [phosphatidylethanolamine biosynthetic process]
GO:0006656 [phosphatidylcholine biosynthetic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008195 [phosphatidate phosphatase activity]
GO:0009062 [fatty acid catabolic process]
GO:0016311 [dephosphorylation]
GO:0019432 [triglyceride biosynthetic process]
GO:0031965 [nuclear membrane]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046474 [glycerophospholipid biosynthetic process]
Show all
 896 aa
99.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.