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IL6ST

CANCER ATLAS

Gene description

 Interleukin 6 signal transducer

Protein class

 Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010558
CAB025784

GENE INFORMATION

Gene name

 IL6ST (HGNC Symbol)

Synonyms

 CD130, GP130

Description

 Interleukin 6 signal transducer (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

Chromosome

 5

Cytoband

 q11.2

Chromosome location (bp)

 55935095 - 55994993

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134352 (version 83.38)

Entrez gene

 3572

UniProt

 P40189 (UniProt - Evidence at protein level)

neXtProt

 NX_P40189

Antibodypedia

 IL6ST antibodies

PROTEIN BROWSER
IL6ST-001
IL6ST-003
IL6ST-005
IL6ST-007
IL6ST-011
IL6ST-012
IL6ST-201
IL6ST-202
IL6ST-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL6ST-001
ENSP00000370698
ENST00000381298
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004921 [interleukin-11 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0005977 [glycogen metabolic process]
GO:0007165 [signal transduction]
GO:0008284 [positive regulation of cell proliferation]
GO:0008593 [regulation of Notch signaling pathway]
GO:0009897 [external side of plasma membrane]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019970 [interleukin-11 binding]
GO:0019981 [interleukin-6 binding]
GO:0030425 [dendrite]
GO:0034097 [response to cytokine]
GO:0038154 [interleukin-11-mediated signaling pathway]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0044297 [cell body]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048711 [positive regulation of astrocyte differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 918 aa
103.5 kDa 		Yes 1
IL6ST-003
ENSP00000370693
ENST00000381293
Q5FC05 [Direct mapping]
IL6ST nirs variant 3; Interleukin-6 receptor subunit beta
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 203 aa
23 kDa 		Yes 0
IL6ST-005
ENSP00000370686
ENST00000381286
Q5FC02 [Direct mapping]
IL6ST nirs variant 6; Interleukin-6 receptor subunit beta
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 66 aa
7.5 kDa 		Yes 0
IL6ST-007
ENSP00000435399
ENST00000522633
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019981 [interleukin-6 binding]
GO:0034097 [response to cytokine]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 329 aa
37.5 kDa 		Yes 0
IL6ST-011
ENSP00000462158
ENST00000502326
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019981 [interleukin-6 binding]
GO:0034097 [response to cytokine]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 918 aa
103.5 kDa 		Yes 1
IL6ST-012
ENSP00000370694
ENST00000381294
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
A0A0A0N0L2 [Target identity:100%; Query identity:100%]
IL6ST isoform 4
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019981 [interleukin-6 binding]
GO:0034097 [response to cytokine]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 857 aa
96.3 kDa 		Yes 1
IL6ST-201
ENSP00000338799
ENST00000336909
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019981 [interleukin-6 binding]
GO:0034097 [response to cytokine]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 918 aa
103.5 kDa 		Yes 1
IL6ST-202
ENSP00000370687
ENST00000381287
P40189 [Direct mapping]
Interleukin-6 receptor subunit beta
Show all
CD markers
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002675 [positive regulation of acute inflammatory response]
GO:0002821 [positive regulation of adaptive immune response]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0004915 [interleukin-6 receptor activity]
GO:0004923 [leukemia inhibitory factor receptor activity]
GO:0004924 [oncostatin-M receptor activity]
GO:0005127 [ciliary neurotrophic factor receptor binding]
GO:0005138 [interleukin-6 receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005896 [interleukin-6 receptor complex]
GO:0005900 [oncostatin-M receptor complex]
GO:0008284 [positive regulation of cell proliferation]
GO:0010575 [positive regulation of vascular endothelial growth factor production]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019838 [growth factor binding]
GO:0019981 [interleukin-6 binding]
GO:0034097 [response to cytokine]
GO:0038165 [oncostatin-M-mediated signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0042517 [positive regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0045509 [interleukin-27 receptor activity]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048861 [leukemia inhibitory factor signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070104 [negative regulation of interleukin-6-mediated signaling pathway]
GO:0070106 [interleukin-27-mediated signaling pathway]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
Show all
 329 aa
37.5 kDa 		Yes 0
IL6ST-203
ENSP00000463896
ENST00000396816
Q5FC07 [Direct mapping]
IL6ST nirs variant 1; Interleukin-6 receptor subunit beta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Other Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 55 aa
6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.