Expression of FST in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Follistatin

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Testis cancer

STAINING SUMMARY

HPA018155	CAB026025

GENE INFORMATION
Gene name	FST (HGNC Symbol)
Synonyms	FS
Description	Follistatin (HGNC Symbol)
Entrez gene summary	Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q11.2
Chromosome location (bp)	53480409 - 53487134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134363 (version 83.38)
Entrez gene	10468
UniProt	P19883 (UniProt - Evidence at protein level)
neXtProt	NX_P19883
Antibodypedia	FST antibodies

PROTEIN BROWSER

FST-001	FST-003	FST-004	FST-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FST-001 ENSP00000256759 ENST00000256759	P19883 [Direct mapping] Follistatin A0A024QZU6 [Target identity:100%; Query identity:100%] Follistatin, isoform CRA_c Show all	MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0032926 [negative regulation of activin receptor signaling pathway] GO:0043395 [heparan sulfate proteoglycan binding] GO:0048185 [activin binding] GO:0051798 [positive regulation of hair follicle development] Show all	344 aa 38 kDa	Yes	0
FST-003 ENSP00000380151 ENST00000396947	P19883 [Direct mapping] Follistatin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0002244 [hematopoietic progenitor cell differentiation] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0032926 [negative regulation of activin receptor signaling pathway] GO:0048185 [activin binding] GO:0051798 [positive regulation of hair follicle development] Show all	317 aa 34.8 kDa	Yes	0
FST-004 ENSP00000426315 ENST00000504226	H0YA75 [Direct mapping] Follistatin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	215 aa 23.5 kDa	No	0
FST-005 ENSP00000426971 ENST00000497789	H0YAF9 [Direct mapping] Follistatin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	102 aa 10.7 kDa	No	0