Cell atlas - CRB1 - The Human Protein Atlas

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CRB1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CRB1
Gene description	Crumbs family member 1, photoreceptor morphogenesis associated
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enriched (HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA061250
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA061250	SH-SY5Y	Vesicles
	HPA061250	U-2 OS	Vesicles

GENE INFORMATION
Gene name	CRB1 (HGNC Symbol)
Synonyms	LCA8, RP12
Description	Crumbs family member 1, photoreceptor morphogenesis associated (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	197268204 - 197478455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134376 (version 83.38)
Entrez gene	23418
UniProt	P82279 (UniProt - Evidence at protein level)
neXtProt	NX_P82279
Antibodypedia	CRB1 antibodies

PROTEIN BROWSER

CRB1-002	CRB1-003	CRB1-004	CRB1-005	CRB1-201	CRB1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRB1-002 ENSP00000395407 ENST00000448952	A0A0C4DG35 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	42 aa 4.6 kDa	No	0
CRB1-003 ENSP00000356367 ENST00000367397	A0A075B6G4 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	674 aa 74.7 kDa	No	0
CRB1-004 ENSP00000356370 ENST00000367400	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005902 [microvillus] GO:0007009 [plasma membrane organization] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0042462 [eye photoreceptor cell development] GO:0061024 [membrane organization] Show all	1406 aa 154.2 kDa	Yes	1
CRB1-005 ENSP00000356369 ENST00000367399	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] Show all	1294 aa 142.1 kDa	Yes	1
CRB1-201 ENSP00000438786 ENST00000535699	F5H0L2 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	1382 aa 151.2 kDa	No	1
CRB1-202 ENSP00000438091 ENST00000538660	P82279 [Direct mapping] Protein crumbs homolog 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007163 [establishment or maintenance of cell polarity] GO:0007267 [cell-cell signaling] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] Show all	870 aa 95 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.