We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
ERN2
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ERN2

Gene description

Endoplasmic reticulum to nucleus signaling 2

Protein class

Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Group enriched (stomach, colon, cervix, uterine, gallbladder, rectum, duodenum, small intestine)
GTEx:Tissue enhanced (stomach, salivary gland, colon)
FANTOM5:Tissue enhanced (gallbladder)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression i several tissues, most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Uncertain based on 1 antibody.
HPA016558
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (stomach, colon, cervix, uterine, gallbladder, rectum, duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, salivary gland, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder)

GENE INFORMATION

Gene name

ERN2 (HGNC Symbol)

Synonyms

IRE1b

Description

Endoplasmic reticulum to nucleus signaling 2 (HGNC Symbol)

Entrez gene summary

Chromosome

16

Cytoband

p12.2

Chromosome location (bp)

23690309 - 23713500

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000134398 (version 83.38)

Entrez gene

10595

UniProt

Q76MJ5 (UniProt - Evidence at protein level)

neXtProt

NX_Q76MJ5

Antibodypedia

ERN2 antibodies

PROTEIN BROWSER

ERN2-001
ERN2-002
ERN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERN2-001
ENSP00000256797
ENST00000256797
Q76MJ5 [Direct mapping]
Serine/threonine-protein kinase/endoribonuclease IRE2 Serine/threonine-protein kinase Endoribonuclease
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0004519 [endonuclease activity]
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006351 [transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0016021 [integral component of membrane]
GO:0016075 [rRNA catabolic process]
GO:0030263 [apoptotic chromosome condensation]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:1990604 [IRE1-TRAF2-ASK1 complex]
Show all
926 aa
102.5 kDa
Yes 2
ERN2-002
ENSP00000413812
ENST00000457008
E7ETG2 [Direct mapping]
Serine/threonine-protein kinase/endoribonuclease IRE2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
Show all
874 aa
96.7 kDa
Yes 0
ERN2-201
ENSP00000489461
ENST00000634482
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004540 [ribonuclease activity]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006397 [mRNA processing]
GO:0006468 [protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:1990604 [IRE1-TRAF2-ASK1 complex]
Show all
974 aa
107.2 kDa
No 2

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.