Cell atlas - NARS - The Human Protein Atlas

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NARS

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	NARS
Gene description	Asparaginyl-tRNA synthetase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA040017
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040017	A-431	Cytosol
	HPA040017	U-2 OS	Cytosol
	HPA040017	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NARS (HGNC Symbol)
Synonyms	NARS1
Description	Asparaginyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.31
Chromosome location (bp)	57600656 - 57622213
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134440 (version 83.38)
Entrez gene	4677
UniProt	O43776 (UniProt - Evidence at protein level)
neXtProt	NX_O43776
Antibodypedia	NARS antibodies

PROTEIN BROWSER

NARS-001	NARS-005	NARS-006	NARS-007	NARS-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NARS-001 ENSP00000256854 ENST00000256854	O43776 [Direct mapping] Asparagine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004816 [asparagine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006421 [asparaginyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0070062 [extracellular exosome] Show all	548 aa 62.9 kDa	No	0
NARS-005 ENSP00000466606 ENST00000587675	K7EMQ6 [Direct mapping] Asparagine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004816 [asparagine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006421 [asparaginyl-tRNA aminoacylation] Show all	128 aa 14.6 kDa	No	0
NARS-006 ENSP00000467421 ENST00000588661	K7EPK2 [Direct mapping] Asparagine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004816 [asparagine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006421 [asparaginyl-tRNA aminoacylation] Show all	163 aa 18.7 kDa	No	0
NARS-007 ENSP00000467651 ENST00000591599	K7EQ35 [Direct mapping] Asparagine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004816 [asparagine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006421 [asparaginyl-tRNA aminoacylation] Show all	167 aa 18.9 kDa	No	0
NARS-008 ENSP00000464899 ENST00000587194	K7EIU7 [Direct mapping] Asparagine--tRNA ligase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004816 [asparagine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006421 [asparaginyl-tRNA aminoacylation] Show all	162 aa 18.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.