Tissue expression of GRP - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GRP
Gene description	Gastrin-releasing peptide
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, thyroid gland)
GTEx:	Tissue enhanced (stomach, hippocampus)
FANTOM5:	Tissue enhanced (retina, pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (stomach, hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (retina, pituitary gland)

GENE INFORMATION
Gene name	GRP
Synonyms
Description	Gastrin-releasing peptide (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. Its preproprotein, following cleavage of a signal peptide, is further processed to produce either the 27 aa gastrin-releasing peptide or the 10 aa neuromedin C. These smaller peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q21.32
Chromosome location (bp)	59220168 - 59230774
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134443 (version 83.38)
Entrez gene	2922
UniProt	P07492 (UniProt - Evidence at protein level)
neXtProt	NX_P07492
Antibodypedia	GRP antibodies

PROTEIN BROWSER

GRP-001	GRP-002	GRP-003	GRP-004	GRP-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GRP-001 ENSP00000256857 ENST00000256857	P07492 [Direct mapping] Gastrin-releasing peptide Neuromedin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] Show all	148 aa 16.2 kDa	Yes	0
GRP-002 ENSP00000389696 ENST00000420468	P07492 [Direct mapping] Gastrin-releasing peptide Neuromedin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] Show all	141 aa 15.5 kDa	Yes	0
GRP-003 ENSP00000434101 ENST00000529320	P07492 [Direct mapping] Gastrin-releasing peptide Neuromedin-C Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005184 [neuropeptide hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0007218 [neuropeptide signaling pathway] Show all	138 aa 15.2 kDa	Yes	0
GRP-004 ENSP00000397814 ENST00000456142	H0Y5C5 [Direct mapping] Gastrin-releasing peptide Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.6 kDa	No	0
GRP-005 ENSP00000431579 ENST00000530323	H0YCH3 [Direct mapping] Gastrin-releasing peptide Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 3.7 kDa	No	0