Tissue expression of HRH4 - Summary - The Human Protein Atlas

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HRH4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HRH4
Gene description	Histamine receptor H4
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Not detected
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA035009
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	HRH4 (HGNC Symbol)
Synonyms	AXOR35, GPCR105, GPRv53, H4R, HH4R
Description	Histamine receptor H4 (HGNC Symbol)
Entrez gene summary	Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	24460629 - 24479957
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134489 (version 83.38)
Entrez gene	59340
UniProt	Q9H3N8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H3N8
Antibodypedia	HRH4 antibodies

PROTEIN BROWSER

HRH4-001	HRH4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRH4-001 ENSP00000256906 ENST00000256906	Q9H3N8 [Direct mapping] Histamine H4 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007606 [sensory perception of chemical stimulus] GO:0008150 [biological_process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043408 [regulation of MAPK cascade] GO:0051381 [histamine binding] Show all	390 aa 44.5 kDa	No	7
HRH4-002 ENSP00000402526 ENST00000426880	Q9H3N8 [Direct mapping] Histamine H4 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004969 [histamine receptor activity] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007194 [negative regulation of adenylate cyclase activity] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007606 [sensory perception of chemical stimulus] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] GO:0043408 [regulation of MAPK cascade] GO:0051381 [histamine binding] Show all	302 aa 34.5 kDa	No	5

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.