Tissue expression of CABLES1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CABLES1
Gene description	Cdk5 and Abl enzyme substrate 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (parathyroid gland)
GTEx:	Tissue enhanced (caudate)
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	CABLES1 (HGNC Symbol)
Synonyms	FLJ35924, HsT2563
Description	Cdk5 and Abl enzyme substrate 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Chromosome	18
Cytoband	q11.2
Chromosome location (bp)	23134564 - 23260467
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134508 (version 83.38)
Entrez gene	91768
UniProt	Q8TDN4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDN4
Antibodypedia	CABLES1 antibodies

PROTEIN BROWSER

CABLES1-001	CABLES1-002	CABLES1-003	CABLES1-004	CABLES1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CABLES1-001 ENSP00000256925 ENST00000256925	Q8TDN4 [Direct mapping] CDK5 and ABL1 enzyme substrate 1 A7K6Y5 [Target identity:100%; Query identity:100%] CDK5 and Abl enzyme substrate 1; Cdk5 and ABL1 enzyme substrate 1 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007049 [cell cycle] GO:0007596 [blood coagulation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	633 aa 67.6 kDa	Yes	0
CABLES1-002 ENSP00000413851 ENST00000420687	Q8TDN4 [Direct mapping] CDK5 and ABL1 enzyme substrate 1 A0A024RC20 [Target identity:100%; Query identity:100%] Cdk5 and Abl enzyme substrate 1, isoform CRA_a Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007049 [cell cycle] GO:0007596 [blood coagulation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	368 aa 41.9 kDa	No	0
CABLES1-003 ENSP00000383321 ENST00000400473	Q8TDN4 [Direct mapping] CDK5 and ABL1 enzyme substrate 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007049 [cell cycle] GO:0007596 [blood coagulation] GO:0051301 [cell division] GO:0051726 [regulation of cell cycle] Show all	306 aa 34.6 kDa	No	0
CABLES1-004 ENSP00000461994 ENST00000580153	A0A0G2JLG8 [Direct mapping] CDK5 and ABL1 enzyme substrate 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1.1 kDa	No	0
CABLES1-008 ENSP00000476575 ENST00000582882	V9GYB4 [Direct mapping] CDK5 and ABL1 enzyme substrate 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051726 [regulation of cell cycle] Show all	163 aa 18 kDa	No	0