Tissue expression of SOX5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SOX5
Gene description	SRY (sex determining region Y)-box 5
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Tissue enhanced (testis, pituitary gland)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis, pituitary gland)

GENE INFORMATION
Gene name	SOX5 (HGNC Symbol)
Synonyms	L-SOX5, MGC35153
Description	SRY (sex determining region Y)-box 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	23529500 - 23951032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134532 (version 83.38)
Entrez gene	6660
UniProt	P35711 (UniProt - Evidence at protein level)
neXtProt	NX_P35711
Antibodypedia	SOX5 antibodies

PROTEIN BROWSER

SOX5-001	SOX5-002	SOX5-003	SOX5-004	SOX5-007	SOX5-008	SOX5-009	SOX5-010	SOX5-016	SOX5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SOX5-001 ENSP00000379328 ENST00000396007	P35711 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006366 [transcription from RNA polymerase II promoter] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	377 aa 42 kDa	No	0
SOX5-002 ENSP00000398273 ENST00000451604	P35711 [Direct mapping] Transcription factor SOX-5 A0A024RB06 [Target identity:100%; Query identity:100%] SRY (Sex determining region Y)-box 5, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001701 [in utero embryonic development] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0021953 [central nervous system neuron differentiation] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0044212 [transcription regulatory region DNA binding] GO:0044798 [nuclear transcription factor complex] GO:0045165 [cell fate commitment] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046982 [protein heterodimerization activity] GO:0048709 [oligodendrocyte differentiation] GO:0051216 [cartilage development] GO:0060164 [regulation of timing of neuron differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	763 aa 84 kDa	No	0
SOX5-003 ENSP00000437487 ENST00000546136	P35711 [Direct mapping] Transcription factor SOX-5 T2CYZ2 [Target identity:100%; Query identity:100%] Transcription factor SOX-5 variant 6 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006366 [transcription from RNA polymerase II promoter] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	750 aa 82.5 kDa	No	0
SOX5-004 ENSP00000393240 ENST00000441133	G3V0H1 [Direct mapping] SRY (Sex determining region Y)-box 5, isoform CRA_f; Transcription factor SOX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		128 aa 14 kDa	No	0
SOX5-007 ENSP00000443520 ENST00000545921	P35711 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006366 [transcription from RNA polymerase II promoter] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	753 aa 82.8 kDa	No	0
SOX5-008 ENSP00000439832 ENST00000537393	F5H0I3 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		728 aa 80.1 kDa	No	0
SOX5-009 ENSP00000441973 ENST00000541536	P35711 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006366 [transcription from RNA polymerase II promoter] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	642 aa 71 kDa	No	0
SOX5-010 ENSP00000441579 ENST00000538083	F5GWL1 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 15.7 kDa	No	0
SOX5-016 ENSP00000442119 ENST00000541847	F5H876 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26.7 kDa	No	0
SOX5-201 ENSP00000370788 ENST00000381381	P35711 [Direct mapping] Transcription factor SOX-5 Show all	Predicted intracellular proteins Transcription factors Other all-alpha-helical DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0006366 [transcription from RNA polymerase II promoter] GO:0032332 [positive regulation of chondrocyte differentiation] GO:0061036 [positive regulation of cartilage development] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:2000741 [positive regulation of mesenchymal stem cell differentiation] Show all	642 aa 71 kDa	No	0