Expression of KLRD1 in cancer - Summary

CANCER ATLAS

Gene description

Killer cell lectin-like receptor subfamily D, member 1

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA069688

GENE INFORMATION
Gene name	KLRD1 (HGNC Symbol)
Synonyms	CD94
Description	Killer cell lectin-like receptor subfamily D, member 1 (HGNC Symbol)
Entrez gene summary	Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10226058 - 10329600
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134539 (version 83.38)
Entrez gene	3824
UniProt	Q13241 (UniProt - Evidence at protein level)
neXtProt	NX_Q13241
Antibodypedia	KLRD1 antibodies

PROTEIN BROWSER

KLRD1-001	KLRD1-002	KLRD1-004	KLRD1-006	KLRD1-012	KLRD1-201	KLRD1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLRD1-001 ENSP00000371333 ENST00000381908	Q13241 [Direct mapping] Natural killer cells antigen CD94 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002228 [natural killer cell mediated immunity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0009897 [external side of plasma membrane] GO:0016021 [integral component of membrane] GO:0023024 [MHC class I protein complex binding] GO:0023030 [MHC class Ib protein binding, via antigen binding groove] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:1990405 [protein antigen binding] Show all	179 aa 20.5 kDa	No	1
KLRD1-002 ENSP00000438669 ENST00000544747	F5H2B7 [Direct mapping] Natural killer cells antigen CD94 Show all	Predicted intracellular proteins Show all		139 aa 16 kDa	No	0
KLRD1-004 ENSP00000441074 ENST00000543420	F5GX94 [Direct mapping] Natural killer cells antigen CD94 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	106 aa 11.9 kDa	No	1
KLRD1-006 ENSP00000443584 ENST00000543777	F6WZH4 [Direct mapping] Natural killer cells antigen CD94 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	158 aa 18.3 kDa	No	1
KLRD1-012 ENSP00000437880 ENST00000539792	H0YFB8 [Direct mapping] Natural killer cells antigen CD94 Show all	Predicted intracellular proteins Show all		51 aa 5.8 kDa	No	0
KLRD1-201 ENSP00000338130 ENST00000336164	Q13241 [Direct mapping] Natural killer cells antigen CD94 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002228 [natural killer cell mediated immunity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0023024 [MHC class I protein complex binding] GO:0023030 [MHC class Ib protein binding, via antigen binding groove] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:1990405 [protein antigen binding] Show all	179 aa 20.5 kDa	No	1
KLRD1-202 ENSP00000310929 ENST00000350274	Q13241 [Direct mapping] Natural killer cells antigen CD94 Show all	CD markers Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002228 [natural killer cell mediated immunity] GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0023024 [MHC class I protein complex binding] GO:0023030 [MHC class Ib protein binding, via antigen binding groove] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0045087 [innate immune response] GO:0050776 [regulation of immune response] GO:1990405 [protein antigen binding] Show all	148 aa 17.1 kDa	No	0