Cell atlas - KLRC1 - The Human Protein Atlas

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KLRC1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	KLRC1
Gene description	Killer cell lectin-like receptor subfamily C, member 1
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058052
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058052	A549	Plasma membrane	Intensity
	HPA058052	HeLa	Plasma membrane
	HPA058052	U-2 OS	Plasma membrane	Intensity

GENE INFORMATION
Gene name	KLRC1 (HGNC Symbol)
Synonyms	CD159a, NKG2, NKG2-A, NKG2-B
Description	Killer cell lectin-like receptor subfamily C, member 1 (HGNC Symbol)
Entrez gene summary	Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10442264 - 10454685
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134545 (version 83.38)
Entrez gene	3821
UniProt	P26715 (UniProt - Evidence at protein level)
neXtProt	NX_P26715
Antibodypedia	KLRC1 antibodies

PROTEIN BROWSER

KLRC1-002	KLRC1-003	KLRC1-004	KLRC1-006	KLRC1-010	KLRC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLRC1-002 ENSP00000352064 ENST00000359151	P26715 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0023024 [MHC class I protein complex binding] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	233 aa 26.3 kDa	No	1
KLRC1-003 ENSP00000385304 ENST00000408006	P26715 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0023024 [MHC class I protein complex binding] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	215 aa 24.2 kDa	No	1
KLRC1-004 ENSP00000256965 ENST00000347831	P26715 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0023024 [MHC class I protein complex binding] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	215 aa 24.2 kDa	No	1
KLRC1-006 ENSP00000442545 ENST00000543893	H0YGB7 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	Predicted intracellular proteins Show all		77 aa 8.9 kDa	No	0
KLRC1-010 ENSP00000441432 ENST00000536188	F5GYZ0 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	228 aa 25.7 kDa	No	1
KLRC1-201 ENSP00000438038 ENST00000544822	P26715 [Direct mapping] NKG2-A/NKG2-B type II integral membrane protein Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0023024 [MHC class I protein complex binding] GO:0030246 [carbohydrate binding] GO:0043235 [receptor complex] GO:0050776 [regulation of immune response] Show all	233 aa 26.3 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.