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MYBPC3

CANCER ATLAS

Gene description

 Myosin binding protein C, cardiac

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040147
HPA043898

GENE INFORMATION

Gene name

 MYBPC3 (HGNC Symbol)

Synonyms

 CMH4, FHC, MYBP-C

Description

 Myosin binding protein C, cardiac (HGNC Symbol)

Entrez gene summary

 MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p11.2

Chromosome location (bp)

 47331397 - 47352702

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134571 (version 83.38)

Entrez gene

 4607

UniProt

 Q14896 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14896

Antibodypedia

 MYBPC3 antibodies

PROTEIN BROWSER
MYBPC3-001
MYBPC3-201
MYBPC3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYBPC3-001
ENSP00000442795
ENST00000545968
Q14896 [Direct mapping]
Myosin-binding protein C, cardiac-type
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001671 [ATPase activator activity]
GO:0002027 [regulation of heart rate]
GO:0003007 [heart morphogenesis]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005863 [striated muscle myosin thick filament]
GO:0006936 [muscle contraction]
GO:0006942 [regulation of striated muscle contraction]
GO:0007155 [cell adhesion]
GO:0008016 [regulation of heart contraction]
GO:0008307 [structural constituent of muscle]
GO:0014705 [C zone]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030049 [muscle filament sliding]
GO:0031034 [myosin filament assembly]
GO:0031432 [titin binding]
GO:0031672 [A band]
GO:0032036 [myosin heavy chain binding]
GO:0032781 [positive regulation of ATPase activity]
GO:0032971 [regulation of muscle filament sliding]
GO:0042802 [identical protein binding]
GO:0045214 [sarcomere organization]
GO:0046872 [metal ion binding]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
Show all
 1274 aa
140.8 kDa 		No 0
MYBPC3-201
ENSP00000256993
ENST00000256993
A0A0A0MQU5 [Direct mapping]
Myosin-binding protein C, cardiac-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1274 aa
140.7 kDa 		No 0
MYBPC3-202
ENSP00000382193
ENST00000399249
A8MXZ9 [Direct mapping]
Myosin-binding protein C, cardiac-type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1274 aa
140.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.