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Rare case of urothelial cancer displayed strong cytoplasmic staining. Moderate cytoplasmic and/or membranous staining was observed in few cases of cervical, lung, skin and urothelial cancers. Remaining cancer tissues were weakly stained or negative.
Several squamous cell carcinomas and urothelial cancers showed moderate to strong cytoplasmic positivity. Malignant cells in general were negative.
GENE INFORMATION
Gene name
DSC3 (HGNC Symbol)
Synonyms
CDHF3, DSC, DSC1, DSC2, DSC4
Description
Desmocollin 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
