Expression of DAGLA in cancer - Summary

CANCER ATLAS

Gene description

Diacylglycerol lipase, alpha

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA062497

GENE INFORMATION
Gene name	DAGLA (HGNC Symbol)
Synonyms	C11orf11, DAGLALPHA, KIAA0659, NSDDR
Description	Diacylglycerol lipase, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61680433 - 61747001
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134780 (version 83.38)
Entrez gene	747
UniProt	Q9Y4D2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y4D2
Antibodypedia	DAGLA antibodies

PROTEIN BROWSER

DAGLA-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAGLA-001 ENSP00000257215 ENST00000257215	Q9Y4D2 [Direct mapping] Sn1-specific diacylglycerol lipase alpha A0A024R517 [Target identity:100%; Query identity:100%] Chromosome 11 open reading frame 11, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006629 [lipid metabolic process] GO:0007405 [neuroblast proliferation] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016298 [lipase activity] GO:0019369 [arachidonic acid metabolic process] GO:0022008 [neurogenesis] GO:0030168 [platelet activation] GO:0042136 [neurotransmitter biosynthetic process] GO:0043196 [varicosity] GO:0046340 [diacylglycerol catabolic process] GO:0046872 [metal ion binding] GO:0071926 [endocannabinoid signaling pathway] GO:0098588 [bounding membrane of organelle] Show all	1042 aa 115 kDa	No	6