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DHX34

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GENERAL INFORMATION

Gene name

 DHX34

Gene description

 DEAH (Asp-Glu-Ala-His) box polypeptide 34

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus & intermediate filaments.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (uncertain), Intermediate filaments (uncertain)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Uncertain based on 2 antibodies.
HPA042159 , HPA043558
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus & intermediate filaments.

Main location

 Nucleus (uncertain), Intermediate filaments (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042159 A-431 Intermediate filaments Intensity
HPA042159 U-2 OS No staining    
HPA042159 U-251 MG No staining    
HPA043558 A-431 Nucleoplasm
HPA043558 U-2 OS Nucleus
HPA043558 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 DHX34 (HGNC Symbol)

Synonyms

 DDX34, KIAA0134

Description

 DEAH (Asp-Glu-Ala-His) box polypeptide 34 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47349281 - 47382704

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134815 (version 83.38)

Entrez gene

 9704

UniProt

 Q14147 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14147

Antibodypedia

 DHX34 antibodies

PROTEIN BROWSER
DHX34-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX34-001
ENSP00000331907
ENST00000328771
Q14147 [Direct mapping]
Probable ATP-dependent RNA helicase DHX34
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:2000623 [negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
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 1143 aa
128.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.