Expression of APLNR in cancer - Summary

CANCER ATLAS

Gene description

Apelin receptor

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025842

GENE INFORMATION
Gene name	APLNR (HGNC Symbol)
Synonyms	AGTRL1, APJ, APJR, FLJ90771
Description	Apelin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]
Chromosome	11
Cytoband	q12.1
Chromosome location (bp)	57233577 - 57237314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134817 (version 83.38)
Entrez gene	187
UniProt	P35414 (UniProt - Evidence at protein level)
neXtProt	NX_P35414
Antibodypedia	APLNR antibodies

PROTEIN BROWSER

APLNR-004	APLNR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APLNR-004 ENSP00000475344 ENST00000606794	P35414 [Direct mapping] Apelin receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007369 [gastrulation] GO:0007507 [heart development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0050878 [regulation of body fluid levels] Show all	380 aa 42.7 kDa	No	7
APLNR-201 ENSP00000477818 ENST00000611099	P35414 [Direct mapping] Apelin receptor Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004872 [receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007369 [gastrulation] GO:0007507 [heart development] GO:0016021 [integral component of membrane] Show all	380 aa 42.7 kDa	No	7