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C5AR2

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GENERAL INFORMATION

Gene name

 C5AR2

Gene description

 Complement component 5a receptor 2

Protein class

 G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (T-47d, MCF7)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (T-47d, MCF7)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 C5AR2 (HGNC Symbol)

Synonyms

 C5L2, GPR77

Description

 Complement component 5a receptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47332147 - 47347327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134830 (version 83.38)

Entrez gene

 27202

UniProt

 Q9P296 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P296

Antibodypedia

 C5AR2 antibodies

PROTEIN BROWSER
C5AR2-001
C5AR2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
C5AR2-001
ENSP00000472620
ENST00000595464
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
 337 aa
36.1 kDa 		No 7
C5AR2-002
ENSP00000471184
ENST00000600626
Q9P296 [Direct mapping]
C5a anaphylatoxin chemotactic receptor 2
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004944 [C5a anaphylatoxin receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009925 [basal plasma membrane]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0045177 [apical part of cell]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0090024 [negative regulation of neutrophil chemotaxis]
GO:1900165 [negative regulation of interleukin-6 secretion]
GO:2000482 [regulation of interleukin-8 secretion]
Show all
 337 aa
36.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.