Tissue expression of GGACT - Summary - The Human Protein Atlas

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GGACT

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GGACT
Gene description	Gamma-glutamylamine cyclotransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (kidney)
GTEx:	Tissue enhanced (kidney)
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in kidney.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA065320
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (kidney)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	GGACT (HGNC Symbol)
Synonyms	A2LD1
Description	Gamma-glutamylamine cyclotransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene aids in the proteolytic degradation of crosslinked fibrin by breaking down isodipeptide L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin degradation. The reaction catalyzed by the encoded gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a free alkylamine. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Aug 2010]
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	100530164 - 100589528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134864 (version 83.38)
Entrez gene	87769
UniProt	Q9BVM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVM4
Antibodypedia	GGACT antibodies

PROTEIN BROWSER

GGACT-001	GGACT-002	GGACT-003	GGACT-004	GGACT-005	GGACT-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GGACT-001 ENSP00000365426 ENST00000376250	Q9BVM4 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003839 [gamma-glutamylcyclotransferase activity] GO:0005515 [protein binding] GO:0042219 [cellular modified amino acid catabolic process] GO:0070062 [extracellular exosome] Show all	153 aa 17.3 kDa	No	0
GGACT-002 ENSP00000471716 ENST00000471912	M0R0M3 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 2.9 kDa	No	0
GGACT-003 ENSP00000471342 ENST00000492399	M0R217 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.5 kDa	No	0
GGACT-004 ENSP00000472246 ENST00000467518	M0R217 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.5 kDa	No	0
GGACT-005 ENSP00000471322 ENST00000464500	M0R0M3 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 2.9 kDa	No	0
GGACT-201 ENSP00000410449 ENST00000455100	Q9BVM4 [Direct mapping] Gamma-glutamylaminecyclotransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003839 [gamma-glutamylcyclotransferase activity] GO:0005515 [protein binding] GO:0042219 [cellular modified amino acid catabolic process] GO:0070062 [extracellular exosome] Show all	153 aa 17.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.