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A majority of gliomas, colorectal, ovarian, skin, pancreatic and liver cancers showed moderate cytoplasmic staining combined with cases of nuclear positivity. Remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
KDELC1 (HGNC Symbol)
Synonyms
EP58, MGC5302
Description
KDEL (Lys-Asp-Glu-Leu) containing 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. [provided by RefSeq, Jul 2008]