Cell atlas - CARS2 - The Human Protein Atlas

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CARS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nucleoplasm

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CARS2
Gene description	Cysteinyl-tRNA synthetase 2, mitochondrial (putative)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria & nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA041776
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria & nucleoplasm.

Main location

Nucleoplasm (approved), Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA041776	A-431	Nucleoplasm
	HPA041776	A-431	Mitochondria
	HPA041776	U-2 OS	Nucleoplasm
	HPA041776	U-2 OS	Mitochondria
	HPA041776	U-251 MG	Nucleoplasm
	HPA041776	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	CARS2 (HGNC Symbol)
Synonyms	FLJ12118
Description	Cysteinyl-tRNA synthetase 2, mitochondrial (putative) (HGNC Symbol)
Entrez gene summary	This gene encodes a putative member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of cysteine to tRNA molecules. A splice-site mutation in this gene has been associated with a novel progressive myoclonic epilepsy disease with similar symptoms to MERRF syndrome. [provided by RefSeq, Mar 2015]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110641412 - 110713603
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134905 (version 83.38)
Entrez gene	79587
UniProt	Q9HA77 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HA77
Antibodypedia	CARS2 antibodies

PROTEIN BROWSER

CARS2-001	CARS2-022	CARS2-033	CARS2-035

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARS2-001 ENSP00000257347 ENST00000257347	Q9HA77 [Direct mapping] Probable cysteine--tRNA ligase, mitochondrial Show all	Enzymes ENZYME proteins Ligase SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005759 [mitochondrial matrix] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0046872 [metal ion binding] Show all	564 aa 62.2 kDa	No	0
CARS2-022 ENSP00000444655 ENST00000542709	F5H579 [Direct mapping] Probable cysteine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004817 [cysteine-tRNA ligase activity] GO:0005829 [cytosol] GO:0006423 [cysteinyl-tRNA aminoacylation] Show all	181 aa 20.4 kDa	No	0
CARS2-033 ENSP00000443027 ENST00000537743	H0YGF2 [Direct mapping] Probable cysteine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004817 [cysteine-tRNA ligase activity] GO:0005829 [cytosol] GO:0006423 [cysteinyl-tRNA aminoacylation] Show all	92 aa 10.3 kDa	No	0
CARS2-035 ENSP00000480523 ENST00000620794	A0A087WWV1 [Direct mapping] Probable cysteine--tRNA ligase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] Show all	90 aa 9.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.