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Rare liver cancers and head and neck cancers showed moderate cytoplasmic positivity. Remaining cancer types were essentially negative. Plasma was strongly stained and tumor stroma was generally positive.
GENE INFORMATION
Gene name
ADAMTS8 (HGNC Symbol)
Synonyms
ADAM-TS8, FLJ41712, METH2
Description
ADAM metallopeptidase with thrombospondin type 1 motif, 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
