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This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
P25054 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000281 [mitotic cytokinesis] GO:0000776 [kinetochore] GO:0001708 [cell fate specification] GO:0001822 [kidney development] GO:0001942 [hair follicle development] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005881 [cytoplasmic microtubule] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0005923 [bicellular tight junction] GO:0005938 [cell cortex] GO:0006461 [protein complex assembly] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0006974 [cellular response to DNA damage stimulus] GO:0007026 [negative regulation of microtubule depolymerization] GO:0007050 [cell cycle arrest] GO:0007091 [metaphase/anaphase transition of mitotic cell cycle] GO:0007094 [mitotic spindle assembly checkpoint] GO:0007155 [cell adhesion] GO:0007163 [establishment or maintenance of cell polarity] GO:0007389 [pattern specification process] GO:0007409 [axonogenesis] GO:0008013 [beta-catenin binding] GO:0008017 [microtubule binding] GO:0008285 [negative regulation of cell proliferation] GO:0009798 [axis specification] GO:0009952 [anterior/posterior pattern specification] GO:0009953 [dorsal/ventral pattern formation] GO:0009954 [proximal/distal pattern formation] GO:0012501 [programmed cell death] GO:0016055 [Wnt signaling pathway] GO:0016328 [lateral plasma membrane] GO:0016342 [catenin complex] GO:0016477 [cell migration] GO:0019827 [stem cell population maintenance] GO:0019887 [protein kinase regulator activity] GO:0019901 [protein kinase binding] GO:0030027 [lamellipodium] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0030424 [axon] GO:0030425 [dendrite] GO:0030426 [growth cone] GO:0030856 [regulation of epithelial cell differentiation] GO:0030858 [positive regulation of epithelial cell differentiation] GO:0030877 [beta-catenin destruction complex] GO:0031016 [pancreas development] GO:0031116 [positive regulation of microtubule polymerization] GO:0031122 [cytoplasmic microtubule organization] GO:0031175 [neuron projection development] GO:0031253 [cell projection membrane] GO:0031274 [positive regulation of pseudopodium assembly] GO:0031965 [nuclear membrane] GO:0032403 [protein complex binding] GO:0032587 [ruffle membrane] GO:0032886 [regulation of microtubule-based process] GO:0033077 [T cell differentiation in thymus] GO:0035019 [somatic stem cell population maintenance] GO:0035371 [microtubule plus-end] GO:0042483 [negative regulation of odontogenesis] GO:0042493 [response to drug] GO:0042995 [cell projection] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043234 [protein complex] GO:0043409 [negative regulation of MAPK cascade] GO:0043588 [skin development] GO:0044295 [axonal growth cone] GO:0044306 [neuron projection terminus] GO:0044336 [canonical Wnt signaling pathway involved in negative regulation of apoptotic process] GO:0044337 [canonical Wnt signaling pathway involved in positive regulation of apoptotic process] GO:0045202 [synapse] GO:0045295 [gamma-catenin binding] GO:0045595 [regulation of cell differentiation] GO:0045597 [positive regulation of cell differentiation] GO:0045667 [regulation of osteoblast differentiation] GO:0045670 [regulation of osteoclast differentiation] GO:0045732 [positive regulation of protein catabolic process] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045785 [positive regulation of cell adhesion] GO:0046716 [muscle cell cellular homeostasis] GO:0048538 [thymus development] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051010 [microtubule plus-end binding] GO:0051171 [regulation of nitrogen compound metabolic process] GO:0051276 [chromosome organization] GO:0051726 [regulation of cell cycle] GO:0051781 [positive regulation of cell division] GO:0051988 [regulation of attachment of spindle microtubules to kinetochore] GO:0060041 [retina development in camera-type eye] GO:0060070 [canonical Wnt signaling pathway] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0070830 [bicellular tight junction assembly] GO:0070852 [cell body fiber] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:0097305 [response to alcohol] GO:1990090 [cellular response to nerve growth factor stimulus] GO:2000211 [regulation of glutamate metabolic process]
P25054 [Direct mapping] Adenomatous polyposis coli protein
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Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Large Deletions COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)