Expression of HAVCR2 in cancer - Summary

CANCER ATLAS

Gene description

Hepatitis A virus cellular receptor 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB026003

GENE INFORMATION
Gene name	HAVCR2 (HGNC Symbol)
Synonyms	CD366, FLJ14428, Tim-3, TIM3, TIMD3
Description	Hepatitis A virus cellular receptor 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
Chromosome	5
Cytoband	q33.3
Chromosome location (bp)	157085832 - 157142869
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135077 (version 83.38)
Entrez gene	84868
UniProt	Q8TDQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDQ0
Antibodypedia	HAVCR2 antibodies

PROTEIN BROWSER

HAVCR2-001	HAVCR2-004	HAVCR2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAVCR2-001 ENSP00000312002 ENST00000307851	Q8TDQ0 [Direct mapping] Hepatitis A virus cellular receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001819 [positive regulation of cytokine production] GO:0002519 [natural killer cell tolerance induction] GO:0005515 [protein binding] GO:0009986 [cell surface] GO:0010629 [negative regulation of gene expression] GO:0016021 [integral component of membrane] GO:0032720 [negative regulation of tumor necrosis factor production] GO:0032722 [positive regulation of chemokine production] GO:0032732 [positive regulation of interleukin-1 production] GO:0032753 [positive regulation of interleukin-4 production] GO:0043032 [positive regulation of macrophage activation] GO:0045089 [positive regulation of innate immune response] GO:0060135 [maternal process involved in female pregnancy] GO:0070062 [extracellular exosome] GO:1900426 [positive regulation of defense response to bacterium] Show all	301 aa 33.4 kDa	Yes	1
HAVCR2-004 ENSP00000430873 ENST00000522593	E5RHN3 [Direct mapping] Hepatitis A virus cellular receptor 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	273 aa 30.3 kDa	Yes	1
HAVCR2-007 ENSP00000430328 ENST00000524219	E5RFR4 [Direct mapping] Hepatitis A virus cellular receptor 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.2 kDa	No	0