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TAOK3

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GENERAL INFORMATION

Gene name

 TAOK3

Gene description

 TAO kinase 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the mitochondria.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA017160
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the mitochondria.

Main location

 Mitochondria (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA017160 A-431 Mitochondria
HPA017160 U-2 OS Mitochondria
HPA017160 U-251 MG Mitochondria

GENE INFORMATION

Gene name

 TAOK3 (HGNC Symbol)

Synonyms

 DPK, JIK, MAP3K18

Description

 TAO kinase 3 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q24.23

Chromosome location (bp)

 118149801 - 118372945

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135090 (version 83.38)

Entrez gene

 51347

UniProt

 Q9H2K8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2K8

Antibodypedia

 TAOK3 antibodies

PROTEIN BROWSER
«
TAOK3-001
TAOK3-002
TAOK3-003
TAOK3-006
TAOK3-007
TAOK3-008
TAOK3-009
TAOK3-010
TAOK3-011
TAOK3-012
TAOK3-013
TAOK3-014
TAOK3-016
TAOK3-017
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAOK3-001
ENSP00000376317
ENST00000392533
Q9H2K8 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0016740 [transferase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046329 [negative regulation of JNK cascade]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 898 aa
105.4 kDa 		No 0
TAOK3-002
ENSP00000416374
ENST00000419821
Q9H2K8 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0016740 [transferase activity]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042981 [regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046329 [negative regulation of JNK cascade]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 898 aa
105.4 kDa 		No 0
TAOK3-003
ENSP00000437389
ENST00000538601
H0YF68 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 185 aa
20.9 kDa 		No 0
TAOK3-006
ENSP00000443834
ENST00000537952
G3V1Q8 [Direct mapping]
Serine/threonine-protein kinase TAO3; TAO kinase 3, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 438 aa
53.1 kDa 		No 0
TAOK3-007
ENSP00000439620
ENST00000537822
F5H1I2 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 14 aa
1.8 kDa 		No 0
TAOK3-008
ENSP00000443487
ENST00000540561
F5H5C7 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 38 aa
4.7 kDa 		No 0
TAOK3-009
ENSP00000444057
ENST00000541878
F5H005 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 62 aa
6.9 kDa 		No 0
TAOK3-010
ENSP00000440315
ENST00000542902
F5GY38 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 57 aa
6.4 kDa 		No 0
TAOK3-011
ENSP00000438820
ENST00000541186
F5H3L7 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 93 aa
10.8 kDa 		No 0
TAOK3-012
ENSP00000441071
ENST00000542532
F5GX96 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 36 aa
4.1 kDa 		No 0
TAOK3-013
ENSP00000438766
ENST00000539872
F5H0M3 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 18 aa
2.1 kDa 		No 0
TAOK3-014
ENSP00000442541
ENST00000541786
F5H7G4 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 21 aa
2.5 kDa 		No 0
TAOK3-016
ENSP00000443465
ENST00000535570
F5H5E0 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 136 aa
15.4 kDa 		No 0
TAOK3-017
ENSP00000441932
ENST00000536979
F5GWV8 [Direct mapping]
Serine/threonine-protein kinase TAO3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 93 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.