Expression of SDS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Serine dehydratase

Protein class

Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA039230

GENE INFORMATION
Gene name	SDS (HGNC Symbol)
Synonyms	SDH
Description	Serine dehydratase (HGNC Symbol)
Entrez gene summary	This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	113392445 - 113426301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135094 (version 83.38)
Entrez gene	10993
UniProt	P20132 (UniProt - Evidence at protein level)
neXtProt	NX_P20132
Antibodypedia	SDS antibodies

PROTEIN BROWSER

SDS-001	SDS-005	SDS-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDS-001 ENSP00000257549 ENST00000257549	P20132 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Enzymes ENZYME proteins Lyases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003941 [L-serine ammonia-lyase activity] GO:0004794 [L-threonine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006094 [gluconeogenesis] GO:0006520 [cellular amino acid metabolic process] GO:0006565 [L-serine catabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0042803 [protein homodimerization activity] GO:0042866 [pyruvate biosynthetic process] Show all	328 aa 34.6 kDa	No	0
SDS-005 ENSP00000449833 ENST00000552280	F8VW93 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Predicted intracellular proteins Show all	GO:0004794 [L-threonine ammonia-lyase activity] GO:0006520 [cellular amino acid metabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	97 aa 10.1 kDa	No	0
SDS-006 ENSP00000449061 ENST00000547342	F8VXS0 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Predicted intracellular proteins Show all	GO:0004794 [L-threonine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	235 aa 25.3 kDa	No	0