Expression of FBXO21 in cancer - Summary - The Human Protein Atlas

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FBXO21

TISSUE

CELL

CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

CANCER ATLAS

Gene description

F-box protein 21

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA071452

GENE INFORMATION
Gene name	FBXO21 (HGNC Symbol)
Synonyms	FBX21, KIAA0875
Description	F-box protein 21 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.22
Chromosome location (bp)	117141988 - 117190531
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135108 (version 83.38)
Entrez gene	23014
UniProt	O94952 (UniProt - Evidence at transcript level)
neXtProt	NX_O94952
Antibodypedia	FBXO21 antibodies

PROTEIN BROWSER

FBXO21-001	FBXO21-002	FBXO21-003	FBXO21-005	FBXO21-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FBXO21-001 ENSP00000483508 ENST00000622495	O94952 [Direct mapping] F-box only protein 21 A0A024RBL8 [Target identity:100%; Query identity:100%] F-box protein 21, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] Show all	621 aa 71.5 kDa	No	0
FBXO21-002 ENSP00000328187 ENST00000330622	O94952 [Direct mapping] F-box only protein 21 A0A024RBR2 [Target identity:100%; Query identity:100%] F-box protein 21, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000151 [ubiquitin ligase complex] GO:0003677 [DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016567 [protein ubiquitination] Show all	628 aa 72.3 kDa	No	0
FBXO21-003 ENSP00000446973 ENST00000548840	H0YHF6 [Direct mapping] F-box only protein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	225 aa 25.7 kDa	No	0
FBXO21-005 ENSP00000449264 ENST00000550180	H0YIE9 [Direct mapping] F-box only protein 21 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] Show all	505 aa 59.2 kDa	No	0
FBXO21-201 ENSP00000414468 ENST00000427718	Q4G104 [Direct mapping] F-box only protein 21; FBXO21 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	537 aa 62.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.