Cell atlas - DMTF1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DMTF1
Gene description	Cyclin D binding myb-like transcription factor 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	20
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023846
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA023846	A-431	Nucleoplasm
HPA023846	U-2 OS	Nucleoplasm
HPA023846	U-2 OS	Cytosol
HPA023846	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	DMTF1 (HGNC Symbol)
Synonyms	DMP1, DMTF, hDMP1, MRUL
Description	Cyclin D binding myb-like transcription factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Chromosome	7
Cytoband	q21.12
Chromosome location (bp)	87152361 - 87196337
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135164 (version 83.38)
Entrez gene	9988
UniProt	Q9Y222 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y222
Antibodypedia	DMTF1 antibodies

PROTEIN BROWSER

DMTF1-001	DMTF1-002	DMTF1-004	DMTF1-007	DMTF1-008	DMTF1-009	DMTF1-010	DMTF1-011	DMTF1-012	DMTF1-013	DMTF1-014	DMTF1-015	DMTF1-016	DMTF1-018	DMTF1-019	DMTF1-024	DMTF1-025	DMTF1-028	DMTF1-033	DMTF1-038

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DMTF1-001 ENSP00000332171 ENST00000331242	Q9Y222 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007049 [cell cycle] Show all	760 aa 84.5 kDa	No	0
DMTF1-002 ENSP00000378193 ENST00000394703	Q9Y222 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007049 [cell cycle] Show all	760 aa 84.5 kDa	No	0
DMTF1-004 ENSP00000416499 ENST00000425705	C9JFR2 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		191 aa 21.4 kDa	No	0
DMTF1-007 ENSP00000412532 ENST00000432937	Q9Y222 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007049 [cell cycle] Show all	672 aa 74.9 kDa	No	0
DMTF1-008 ENSP00000411858 ENST00000414630	C9J4F7 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.4 kDa	No	0
DMTF1-009 ENSP00000413118 ENST00000428819	C9K0K9 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 2.9 kDa	No	0
DMTF1-010 ENSP00000397490 ENST00000453049	C9J8Y5 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.9 kDa	No	0
DMTF1-011 ENSP00000401129 ENST00000446796	C9K0L9 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.3 kDa	No	0
DMTF1-012 ENSP00000406384 ENST00000420131		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		10 aa 1.1 kDa	No	0
DMTF1-013 ENSP00000387712 ENST00000449088	C9JZZ6 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 14.9 kDa	No	0
DMTF1-014 ENSP00000412734 ENST00000448598	C9J4F7 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		49 aa 5.4 kDa	No	0
DMTF1-015 ENSP00000416307 ENST00000430405	C9JGT5 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 19.5 kDa	No	0
DMTF1-016 ENSP00000393370 ENST00000434534	C9JVQ7 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.4 kDa	No	0
DMTF1-018 ENSP00000413722 ENST00000423590	C9JLR5 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.4 kDa	No	0
DMTF1-019 ENSP00000415382 ENST00000432366	C9JED5 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		73 aa 8 kDa	No	0
DMTF1-024 ENSP00000410288 ENST00000454008	H7C388 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 19.5 kDa	No	0
DMTF1-025 ENSP00000402627 ENST00000413276	E7EPA0 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	690 aa 76.9 kDa	No	0
DMTF1-028 ENSP00000463735 ENST00000579592	J3QLW3 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.7 kDa	No	0
DMTF1-033 ENSP00000461920 ENST00000582925	J3KRC1 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		34 aa 3.7 kDa	No	0
DMTF1-038 ENSP00000463239 ENST00000582204	J3QKU5 [Direct mapping] Cyclin-D-binding Myb-like transcription factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	178 aa 19.5 kDa	No	0