Expression of MDFIC in cancer - Summary

CANCER ATLAS

Gene description

MyoD family inhibitor domain containing

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030716

GENE INFORMATION
Gene name	MDFIC (HGNC Symbol)
Synonyms	HIC
Description	MyoD family inhibitor domain containing (HGNC Symbol)
Entrez gene summary	This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Chromosome	7
Cytoband
Chromosome location (bp)	114922154 - 115019916
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135272 (version 83.38)
Entrez gene	29969
UniProt	Q9P1T7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P1T7
Antibodypedia	MDFIC antibodies

PROTEIN BROWSER

MDFIC-001	MDFIC-002	MDFIC-003	MDFIC-004	MDFIC-006	MDFIC-007	MDFIC-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MDFIC-001 ENSP00000377126 ENST00000393486	Q9P1T7 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0006351 [transcription, DNA-templated] GO:0007257 [activation of JUN kinase activity] GO:0008134 [transcription factor binding] GO:0016032 [viral process] GO:0030111 [regulation of Wnt signaling pathway] GO:0030332 [cyclin binding] GO:0030957 [Tat protein binding] GO:0042308 [negative regulation of protein import into nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0050434 [positive regulation of viral transcription] Show all	246 aa 25.8 kDa	No	0
MDFIC-002 ENSP00000401623 ENST00000423503	C9J104 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.1 kDa	No	0
MDFIC-003 ENSP00000412153 ENST00000448022	C9J104 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.1 kDa	No	0
MDFIC-004 ENSP00000392098 ENST00000427207	H7BZY3 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	156 aa 16.8 kDa	No	0
MDFIC-006 ENSP00000418337 ENST00000498196	C9J784 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	135 aa 14.5 kDa	No	1
MDFIC-007 ENSP00000257724 ENST00000257724	J3KN13 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] Show all	355 aa 37 kDa	Yes	0
MDFIC-201 ENSP00000484656 ENST00000614186	J3KN13 [Direct mapping] MyoD family inhibitor domain-containing protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0042308 [negative regulation of protein import into nucleus] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	355 aa 37 kDa	Yes	0