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Most cancer cells were weakly stained or negative. Several cases of gliomas, cervical, breast, colorectal, skin, testis and urothelial cancers displayed moderate cytoplasmic positivity with additional membranous staining in few cases. Rare cases of skin cancer were strongly positive.
GENE INFORMATION
Gene name
GJA10 (HGNC Symbol)
Synonyms
CX62
Description
Gap junction protein, alpha 10, 62kDa (HGNC Symbol)
Entrez gene summary
Connexins, such as GJA10, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits (Sohl et al., 2003 [PubMed 12881038]).[supplied by OMIM, Mar 2008]
