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EHF

CANCER ATLAS

Gene description

 Ets homologous factor

Protein class

 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060734

GENE INFORMATION

Gene name

 EHF (HGNC Symbol)

Synonyms

 ESE3, ESEJ

Description

 Ets homologous factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 34621093 - 34661057

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135373 (version 83.38)

Entrez gene

 26298

UniProt

 Q9NZC4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NZC4

Antibodypedia

 EHF antibodies

PROTEIN BROWSER
EHF-001
EHF-002
EHF-003
EHF-004
EHF-007
EHF-008
EHF-009
EHF-010
EHF-011
EHF-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHF-001
ENSP00000257831
ENST00000257831
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-002
ENSP00000433508
ENST00000530286
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-003
ENSP00000435837
ENST00000533754
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-004
ENSP00000435835
ENST00000531794
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 322 aa
37.4 kDa 		Yes 0
EHF-007
ENSP00000432460
ENST00000532302
E9PQX0 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 158 aa
18.1 kDa 		No 0
EHF-008
ENSP00000436357
ENST00000531728
E9PPS9 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 126 aa
14.3 kDa 		No 0
EHF-009
ENSP00000399733
ENST00000450654
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 277 aa
32.3 kDa 		No 0
EHF-010
ENSP00000432905
ENST00000529527
E9PN75 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 166 aa
19 kDa 		No 0
EHF-011
ENSP00000434395
ENST00000525253
E9PQR6 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 173 aa
19.8 kDa 		No 0
EHF-012
ENSP00000436158
ENST00000527935
E9PPS9 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 126 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.