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ELF5

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GENERAL INFORMATION

Gene name

 ELF5

Gene description

 E74-like factor 5 (ets domain transcription factor)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Group enriched (T-47d, RT4)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA062706
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (T-47d, RT4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062706 Hep G2 No staining    
HPA062706 RT4 Nucleoplasm
HPA062706 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 ELF5

Synonyms

Description

 E74-like factor 5 (ets domain transcription factor) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 34478793 - 34513805

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135374 (version 83.38)

Entrez gene

 2001

UniProt

 Q9UKW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKW6

Antibodypedia

 ELF5 antibodies

PROTEIN BROWSER
ELF5-001
ELF5-002
ELF5-003
ELF5-004
ELF5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELF5-001
ENSP00000257832
ENST00000257832
Q9UKW6 [Direct mapping]
ETS-related transcription factor Elf-5
A8K443 [Target identity:100%; Query identity:100%]
E74-like factor 5 (Ets domain transcription factor), isoform CRA_a; cDNA FLJ78106, highly similar to Homo sapiens E74-like factor 5 (ets domain transcription factor) (ELF5), transcript variant 2, mRNA; cDNA FLJ90716 fis, clone PLACE1008549, highly similar to ETS-related transcription factor Elf-5; cDNA, FLJ92906, Homo sapiens E74-like factor 5 (ets domain transcription factor)(ELF5), mRNA
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 255 aa
30.1 kDa 		No 0
ELF5-002
ENSP00000311010
ENST00000312319
Q9UKW6 [Direct mapping]
ETS-related transcription factor Elf-5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001712 [ectodermal cell fate commitment]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007398 [ectoderm development]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0035019 [somatic stem cell population maintenance]
GO:0043565 [sequence-specific DNA binding]
GO:0045596 [negative regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060644 [mammary gland epithelial cell differentiation]
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 265 aa
31.3 kDa 		No 0
ELF5-003
ENSP00000436386
ENST00000532417
Q9UKW6 [Direct mapping]
ETS-related transcription factor Elf-5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 138 aa
16.1 kDa 		No 0
ELF5-004
ENSP00000407589
ENST00000429939
Q9UKW6 [Direct mapping]
ETS-related transcription factor Elf-5
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008283 [cell proliferation]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 160 aa
18.9 kDa 		No 0
ELF5-201
ENSP00000484521
ENST00000620316
A0A087X1W9 [Direct mapping]
ETS-related transcription factor Elf-5
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Predicted intracellular proteins
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 187 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.