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CD63

CANCER ATLAS

Gene description

 CD63 molecule

Protein class

 CD markers, Plasma proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010088
CAB026356

GENE INFORMATION

Gene name

 CD63 (HGNC Symbol)

Synonyms

 ME491, MLA1, TSPAN30

Description

 CD63 molecule (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 55725323 - 55729707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135404 (version 83.38)

Entrez gene

 967

UniProt

 P08962 (UniProt - Evidence at protein level)

neXtProt

 NX_P08962

Antibodypedia

 CD63 antibodies

PROTEIN BROWSER
«
CD63-001
CD63-002
CD63-003
CD63-004
CD63-006
CD63-007
CD63-008
CD63-009
CD63-010
CD63-011
CD63-012
CD63-014
CD63-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD63-001
ENSP00000447730
ENST00000549117
P08962 [Direct mapping]
CD63 antigen
A0A024RB05 [Target identity:100%; Query identity:100%]
Tetraspanin
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0010633 [negative regulation of epithelial cell migration]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0030855 [epithelial cell differentiation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0032403 [protein complex binding]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0043234 [protein complex]
GO:0043473 [pigmentation]
GO:0045785 [positive regulation of cell adhesion]
GO:0045807 [positive regulation of endocytosis]
GO:0048757 [pigment granule maturation]
GO:0050931 [pigment cell differentiation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 238 aa
25.6 kDa 		No 4
CD63-002
ENSP00000257857
ENST00000257857
P08962 [Direct mapping]
CD63 antigen
A0A024RB05 [Target identity:100%; Query identity:100%]
Tetraspanin
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 238 aa
25.6 kDa 		No 4
CD63-003
ENSP00000449337
ENST00000552692
P08962 [Direct mapping]
CD63 antigen
A0A024RB05 [Target identity:100%; Query identity:100%]
Tetraspanin
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 238 aa
25.6 kDa 		No 4
CD63-004
ENSP00000446807
ENST00000552754
P08962 [Direct mapping]
CD63 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 215 aa
23.4 kDa 		No 3
CD63-006
ENSP00000450191
ENST00000546457
F8VNT9 [Direct mapping]
CD63 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 133 aa
14.3 kDa 		No 3
CD63-007
ENSP00000449281
ENST00000552164
F8VWK8 [Direct mapping]
Tetraspanin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 217 aa
23.4 kDa 		No 3
CD63-008
ENSP00000446752
ENST00000551173
F8W022 [Direct mapping]
Tetraspanin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 215 aa
23.1 kDa 		No 3
CD63-009
ENSP00000447356
ENST00000546939
P08962 [Direct mapping]
CD63 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 156 aa
17.3 kDa 		Yes 1
CD63-010
ENSP00000448091
ENST00000550776
P08962 [Direct mapping]
CD63 antigen
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 156 aa
17.3 kDa 		Yes 1
CD63-011
ENSP00000447938
ENST00000548898
F8VV56 [Direct mapping]
CD63 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 145 aa
16 kDa 		No 1
CD63-012
ENSP00000449684
ENST00000552067
F8VV56 [Direct mapping]
CD63 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 145 aa
16 kDa 		No 1
CD63-014
ENSP00000449654
ENST00000548160
F8VV56 [Direct mapping]
CD63 antigen
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 145 aa
16 kDa 		No 1
CD63-201
ENSP00000393502
ENST00000420846
P08962 [Direct mapping]
CD63 antigen
A0A024RB05 [Target identity:100%; Query identity:100%]
Tetraspanin
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002092 [positive regulation of receptor internalization]
GO:0002576 [platelet degranulation]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007160 [cell-matrix adhesion]
GO:0007596 [blood coagulation]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0030168 [platelet activation]
GO:0031088 [platelet dense granule membrane]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031902 [late endosome membrane]
GO:0031904 [endosome lumen]
GO:0034613 [cellular protein localization]
GO:0035646 [endosome to melanosome transport]
GO:0042470 [melanosome]
GO:0048757 [pigment granule maturation]
GO:0070062 [extracellular exosome]
GO:0097487 [multivesicular body, internal vesicle]
GO:1900746 [regulation of vascular endothelial growth factor signaling pathway]
GO:2000680 [regulation of rubidium ion transport]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 238 aa
25.6 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.