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GDF11

GENERAL INFORMATION

Gene name

 GDF11

Gene description

 Growth differentiation factor 11

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Tissue enhanced (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in the brain and male genital system. Also expressed in peripheral nerves in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA069609
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Seminal vesicle

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

 GDF11 (HGNC Symbol)

Synonyms

 BMP-11

Description

 Growth differentiation factor 11 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 55743280 - 55757278

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135414 (version 83.38)

Entrez gene

 10220

UniProt

 O95390 (UniProt - Evidence at transcript level)

neXtProt

 NX_O95390

Antibodypedia

 GDF11 antibodies

PROTEIN BROWSER
GDF11-001
GDF11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GDF11-001
ENSP00000257868
ENST00000257868
O95390 [Direct mapping]
Growth/differentiation factor 11
A0A024RB20 [Target identity:100%; Query identity:100%]
Growth differentiation factor 11, isoform CRA_a
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001501 [skeletal system development]
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0008083 [growth factor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0021512 [spinal cord anterior/posterior patterning]
GO:0031016 [pancreas development]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0045596 [negative regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0048468 [cell development]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0060021 [palate development]
GO:0060395 [SMAD protein signal transduction]
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 407 aa
45.1 kDa 		Yes 0
GDF11-002
ENSP00000448390
ENST00000546799
H0YI30 [Direct mapping]
Growth/differentiation factor 11
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
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 380 aa
42.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.