Tissue expression of ESPL1 - Summary - The Human Protein Atlas

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ESPL1

TISSUE

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CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	ESPL1
Gene description	Extra spindle pole bodies like 1, separase
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (esophagus, testis)
GTEx:	Tissue enhanced (esophagus, testis)
FANTOM5:	Tissue enhanced (esophagus, colon, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Pending retesting.
Reliability score	Uncertain based on 1 antibody. CAB012185
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (esophagus, colon, tonsil)

GENE INFORMATION
Gene name	ESPL1 (HGNC Symbol)
Synonyms	ESP1, KIAA0165, SEPA
Description	Extra spindle pole bodies like 1, separase (HGNC Symbol)
Entrez gene summary	Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53268299 - 53293643
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135476 (version 83.38)
Entrez gene	9700
UniProt	Q14674 (UniProt - Evidence at protein level)
neXtProt	NX_Q14674
Antibodypedia	ESPL1 antibodies

PROTEIN BROWSER

ESPL1-002	ESPL1-007	ESPL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ESPL1-002 ENSP00000449831 ENST00000552462	Q14674 [Direct mapping] Separin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000278 [mitotic cell cycle] GO:0000910 [cytokinesis] GO:0003824 [catalytic activity] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0040001 [establishment of mitotic spindle localization] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0045875 [negative regulation of sister chromatid cohesion] GO:0051307 [meiotic chromosome separation] GO:0072686 [mitotic spindle] GO:1901970 [positive regulation of mitotic sister chromatid separation] Show all	2120 aa 233.2 kDa	No	1
ESPL1-007 ENSP00000456450 ENST00000553219	H3BRX7 [Direct mapping] Separin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0051307 [meiotic chromosome separation] GO:0072686 [mitotic spindle] GO:1901970 [positive regulation of mitotic sister chromatid separation] Show all	207 aa 22.6 kDa	No	0
ESPL1-201 ENSP00000257934 ENST00000257934	Q14674 [Direct mapping] Separin Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000212 [meiotic spindle organization] GO:0000278 [mitotic cell cycle] GO:0000910 [cytokinesis] GO:0003824 [catalytic activity] GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007127 [meiosis I] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0040001 [establishment of mitotic spindle localization] GO:0045143 [homologous chromosome segregation] GO:0045842 [positive regulation of mitotic metaphase/anaphase transition] GO:0045875 [negative regulation of sister chromatid cohesion] GO:0051307 [meiotic chromosome separation] GO:0072686 [mitotic spindle] GO:1901970 [positive regulation of mitotic sister chromatid separation] Show all	2120 aa 233.2 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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