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ACVR1B

CANCER ATLAS

Gene description

 Activin A receptor, type IB

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA063761

GENE INFORMATION

Gene name

 ACVR1B (HGNC Symbol)

Synonyms

 ActRIB, ACVRLK4, ALK4, SKR2

Description

 Activin A receptor, type IB (HGNC Symbol)

Entrez gene summary

 This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 51951667 - 51997078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135503 (version 83.38)

Entrez gene

 91

UniProt

 P36896 (UniProt - Evidence at protein level)

neXtProt

 NX_P36896

Antibodypedia

 ACVR1B antibodies

PROTEIN BROWSER
ACVR1B-001
ACVR1B-002
ACVR1B-003
ACVR1B-004
ACVR1B-005
ACVR1B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACVR1B-001
ENSP00000442885
ENST00000542485
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
 453 aa
51.7 kDa 		No 1
ACVR1B-002
ENSP00000257963
ENST00000257963
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
 505 aa
56.8 kDa 		Yes 1
ACVR1B-003
ENSP00000397550
ENST00000415850
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
 487 aa
54.3 kDa 		Yes 1
ACVR1B-004
ENSP00000442656
ENST00000541224
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0001942 [hair follicle development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007417 [central nervous system development]
GO:0009966 [regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046545 [development of primary female sexual characteristics]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
 546 aa
61.4 kDa 		Yes 1
ACVR1B-005
ENSP00000390477
ENST00000426655
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
 476 aa
53.4 kDa 		Yes 1
ACVR1B-006
ENSP00000443218
ENST00000536420
F5H5Q2 [Direct mapping]
Activin receptor type-1B
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
 71 aa
8.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.