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PKIB

GENERAL INFORMATION

Gene name

 PKIB

Gene description

 Protein kinase (cAMP-dependent, catalytic) inhibitor beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, placenta)
GTEx:Tissue enriched (cerebellum)
FANTOM5:Group enriched (placenta, cerebellum, pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030156
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, placenta)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin010203040506070RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, cerebellum, pituitary gland)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina0100200300400500600Tags Per Million

GENE INFORMATION

Gene name

 PKIB (HGNC Symbol)

Synonyms

 PRKACN2

Description

 Protein kinase (cAMP-dependent, catalytic) inhibitor beta (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 q22.31

Chromosome location (bp)

 122471917 - 122726373

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135549 (version 83.38)

Entrez gene

 5570

UniProt

 Q9C010 (UniProt - Inferred from homology)

neXtProt

 NX_Q9C010

Antibodypedia

 PKIB antibodies

PROTEIN BROWSER
PKIB-001
PKIB-002
PKIB-003
PKIB-004
PKIB-005
PKIB-006
PKIB-201
PKIB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKIB-001
ENSP00000258014
ENST00000258014
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 85 aa
9.2 kDa 		No 0
PKIB-002
ENSP00000357437
ENST00000368452
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 78 aa
8.5 kDa 		No 0
PKIB-003
ENSP00000357431
ENST00000368446
Q5T0Z6 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 87 aa
9.5 kDa 		No 0
PKIB-004
ENSP00000357433
ENST00000368448
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 78 aa
8.5 kDa 		No 0
PKIB-005
ENSP00000346227
ENST00000354275
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 78 aa
8.5 kDa 		No 0
PKIB-006
ENSP00000376281
ENST00000392491
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 78 aa
8.5 kDa 		No 0
PKIB-201
ENSP00000376280
ENST00000392490
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 78 aa
8.5 kDa 		No 0
PKIB-202
ENSP00000480824
ENST00000615438
Q9C010 [Direct mapping]
cAMP-dependent protein kinase inhibitor beta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006469 [negative regulation of protein kinase activity]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 85 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.