Cell atlas - SEMA4F - The Human Protein Atlas

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SEMA4F

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleus
	Plasma membrane

Human cell
	Centrosome
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SEMA4F
Gene description	Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the plasma membrane & centrosome.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Plasma membrane (approved), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA065969
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the plasma membrane & centrosome.

Main location

Nucleus (approved)

Additional location

Plasma membrane (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA065969	SH-SY5Y	Nucleus
	HPA065969	U-2 OS	Nucleoplasm
	HPA065969	U-251 MG	Nucleoplasm
			Plasma membrane
			Centrosome

GENE INFORMATION
Gene name	SEMA4F (HGNC Symbol)
Synonyms	SEMAM, SEMAW
Description	Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F (HGNC Symbol)
Entrez gene summary	This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74654228 - 74683853
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135622 (version 83.38)
Entrez gene	10505
UniProt	O95754 (UniProt - Evidence at transcript level)
neXtProt	NX_O95754
Antibodypedia	SEMA4F antibodies

PROTEIN BROWSER

SEMA4F-001	SEMA4F-003	SEMA4F-006	SEMA4F-008	SEMA4F-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SEMA4F-001 ENSP00000350547 ENST00000357877	O95754 [Direct mapping] Semaphorin-4F Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0031290 [retinal ganglion cell axon guidance] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	770 aa 83.5 kDa	Yes	1
SEMA4F-003 ENSP00000342675 ENST00000339773	O95754 [Direct mapping] Semaphorin-4F Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001755 [neural crest cell migration] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007267 [cell-cell signaling] GO:0007399 [nervous system development] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0030215 [semaphorin receptor binding] GO:0030335 [positive regulation of cell migration] GO:0045499 [chemorepellent activity] GO:0048843 [negative regulation of axon extension involved in axon guidance] GO:0050919 [negative chemotaxis] GO:0071526 [semaphorin-plexin signaling pathway] Show all	615 aa 66.5 kDa	Yes	1
SEMA4F-006 ENSP00000407698 ENST00000434486	C9K0A1 [Direct mapping] Semaphorin-4F Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] Show all	165 aa 17.9 kDa	Yes	0
SEMA4F-008 ENSP00000409141 ENST00000453930	C9JKW7 [Direct mapping] Semaphorin-4F Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007411 [axon guidance] GO:0016021 [integral component of membrane] Show all	178 aa 19.3 kDa	Yes	0
SEMA4F-201 ENSP00000482238 ENST00000611975	A0A087WYZ7 [Direct mapping] Semaphorin-4F Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0007411 [axon guidance] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	737 aa 80 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.