Tissue expression of GNS - Summary - The Human Protein Atlas

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GNS

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GNS
Gene description	Glucosamine (N-acetyl)-6-sulfatase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA013695 , HPA048508 , CAB026011
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GNS
Synonyms
Description	Glucosamine (N-acetyl)-6-sulfatase (HGNC Symbol)
Entrez gene summary	The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q14.3
Chromosome location (bp)	64713445 - 64759447
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135677 (version 83.38)
Entrez gene	2799
UniProt	P15586 (UniProt - Evidence at protein level)
neXtProt	NX_P15586
Antibodypedia	GNS antibodies

PROTEIN BROWSER

GNS-001	GNS-002	GNS-006	GNS-007	GNS-008	GNS-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNS-001 ENSP00000258145 ENST00000258145	P15586 [Direct mapping] N-acetylglucosamine-6-sulfatase A0A024RBC5 [Target identity:100%; Query identity:100%] Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0042339 [keratan sulfate metabolic process] GO:0042340 [keratan sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	552 aa 62.1 kDa	Yes	0
GNS-002 ENSP00000438497 ENST00000543646	F6S8M0 [Direct mapping] N-acetylglucosamine-6-sulfatase Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005764 [lysosome] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] Show all	584 aa 65.7 kDa	Yes	0
GNS-006 ENSP00000444819 ENST00000542058	P15586 [Direct mapping] N-acetylglucosamine-6-sulfatase Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005515 [protein binding] GO:0005975 [carbohydrate metabolic process] GO:0006027 [glycosaminoglycan catabolic process] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] GO:0042339 [keratan sulfate metabolic process] GO:0042340 [keratan sulfate catabolic process] GO:0043202 [lysosomal lumen] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	532 aa 60 kDa	Yes	0
GNS-007 ENSP00000413130 ENST00000418919	H7C3P4 [Direct mapping] Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID), isoform CRA_b; N-acetylglucosamine-6-sulfatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005764 [lysosome] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] Show all	496 aa 56.4 kDa	No	0
GNS-008 ENSP00000445055 ENST00000545273	F5H4C6 [Direct mapping] N-acetylglucosamine-6-sulfatase Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005764 [lysosome] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] Show all	248 aa 28.5 kDa	No	0
GNS-010 ENSP00000437782 ENST00000540196	H0YFA9 [Direct mapping] N-acetylglucosamine-6-sulfatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005764 [lysosome] GO:0008152 [metabolic process] GO:0008449 [N-acetylglucosamine-6-sulfatase activity] GO:0008484 [sulfuric ester hydrolase activity] GO:0030203 [glycosaminoglycan metabolic process] Show all	303 aa 34.6 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.