Cell atlas - BCO1 - The Human Protein Atlas

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BCO1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments
	Microtubule organizing center

Human cell
	Actin Filaments
	Centrosome

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GENERAL INFORMATION
Gene name	BCO1
Gene description	Beta-carotene oxygenase 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the microtubule organizing center & actin filaments.
RNA cell category	Cell line enhanced (A549, EFO-21, RPTEC TERT1, NTERA-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (uncertain), Microtubule organizing center (uncertain)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA043811
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, EFO-21, RPTEC TERT1, NTERA-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the microtubule organizing center & actin filaments.

Main location

Actin filaments (uncertain), Microtubule organizing center (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043811	A549	Actin filaments	Intensity
	HPA043811	U-2 OS	Microtubule organizing center
	HPA043811	U-251 MG	Actin filaments
	HPA043811	U-251 MG	Microtubule organizing center

GENE INFORMATION
Gene name	BCO1 (HGNC Symbol)
Synonyms	BCDO, BCDO1, BCMO, BCMO1, FLJ10730
Description	Beta-carotene oxygenase 1 (HGNC Symbol)
Entrez gene summary	Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	q23.2
Chromosome location (bp)	81238448 - 81291142
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135697 (version 83.38)
Entrez gene	53630
UniProt	Q9HAY6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAY6
Antibodypedia	BCO1 antibodies

PROTEIN BROWSER

BCO1-001	BCO1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCO1-001 ENSP00000258168 ENST00000258168	Q9HAY6 [Direct mapping] Beta,beta-carotene 15,15'-monooxygenase Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001523 [retinoid metabolic process] GO:0003834 [beta-carotene 15,15'-monooxygenase activity] GO:0004497 [monooxygenase activity] GO:0005829 [cytosol] GO:0007603 [phototransduction, visible light] GO:0035238 [vitamin A biosynthetic process] GO:0042572 [retinol metabolic process] GO:0042574 [retinal metabolic process] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] GO:1901810 [beta-carotene metabolic process] Show all	547 aa 62.6 kDa	No	0
BCO1-003 ENSP00000455219 ENST00000564552	H3BPA2 [Direct mapping] Beta,beta-carotene 15,15'-monooxygenase Show all	Predicted intracellular proteins Show all		162 aa 18.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.