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Several liver cancers exhibited moderate to strong cytoplasmic positivity. Fraction of tumor cells in a single case of carcinoid and ovarian cancer showed strong cytoplasmic immunoreactivity. Rare cases of prostate and pancreatic cancers displayed moderate to strong cytoplasmic and membranous staining. Moderate nuclear positivity was observed in a single case of glioma. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
AGT (HGNC Symbol)
Synonyms
SERPINA8
Description
Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]